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This the main problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both once they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it one should err along the side of caution and let the FDA do its job and demand some investigation be done so your public understands the side effects and dangers of the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on the medications. Researchers discovered that participants using this drug for any year, lost excess weight within a month and have kept the body weight off during the entire 56 weeks from the study. Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which are made up of several active ingredient, which might make them more effective and safer. Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and so it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular may be the fact that at the time of right now there are no long term prescription weight loss supplements that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug may also raise blood pressure and pulse rate, and must not be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must not be used in patients with uncontrolled high hypertension, and also by you aren't heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients for the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. --Participating in support groups which help the family of the addict recover (including Al-Anon or Nar-Anon).