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Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which are made up of more than one active ingredient, which might make them far better and safer. Combo-pilling could be the newest fad or better yet the newest ahead under scrutiny and so it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular could be the fact that as of right now there aren't any long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. 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